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cell permeable smac-n7-ant peptide  (SMAC Corp)

 
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    SMAC Corp cell permeable smac-n7-ant peptide
    Cell Permeable Smac N7 Ant Peptide, supplied by SMAC Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cell-permeable+smac+peptides/smac+peptide/pmc03899364-131-19-21
    Average 90 stars, based on 1 article reviews
    cell permeable smac-n7-ant peptide - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    other:

    Article Title: Molecular targeting of E3 ligases--a therapeutic approach for cancer.
    Article Snippet: Background : The ubiquitin-proteasomal degradation pathway plays a critical role in protein degradation and regulates a wide variety of cellular functions.. This highly conserved post-translational modification of proteolytic processes is mainly carried out by substrate-specific E3 ligases.. The deregulation of E3 ligases contributes to cancer development and their overexpression is often associated with poor prognosis.

    Control:

    Article Title: Conformationally constrained Smac mimetics and the uses thereof
    Article Snippet: PC-3 cells were treated with CDDP, Smac peptides and mimetics alone or in combination for 42 hours and apoptosis was analyzed by Annexin V-FITC staining. .. Consistent with previous studies using cell-permeable Smac peptides, SH-97 up to 50 μM did not induce significantly more apoptosis as compared to untreated cancer cells, while 25 μM CDDP induced 12-15% of cancer cells to undergo apoptosis as compared to control cells (FIG. 10A). ..

    Article Title: Conformationally constrained Smac mimetics and the uses thereof
    Article Snippet: PC-3 cells were treated with CDDP, Smac peptides and mimetics alone or in combination for 42 hours and apoptosis was analyzed by Annexin V-FITC staining. .. Consistent with previous studies using cell-permeable Smac peptides, SH-97 up to 50 μM did not induce significantly more apoptosis as compared to untreated cancer cells, while 25 μM CDDP induced 12-15% of cancer cells to undergo apoptosis as compared to control cells (FIG. 18A). ..

    Derivative Assay:

    Article Title: Promoting apoptosis as a strategy for cancer drug discovery.
    Article Snippet: | Apoptosis is deregulated in many cancers, making it difficult to kill tumours.. Drugs that restore the normal apoptotic pathways have the potential for effectively treating cancers that depend on aberrations of the apoptotic pathway to stay alive.. Apoptosis targets that are currently being explored for cancer drug discovery include the tumournecrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors, the BCL2 family of anti-apoptotic proteins, inhibitor of apoptosis (IAP) proteins and MDM2.



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    Relative viability (MTS assay) of Caki1 cells treated with indicated concentrations of Smac-Ant peptide <t>(AVPIAQK)</t> alone or in combination with cisplatin (50 μ g ml −1 ) for 24 h ( A ). The cells were exposed to 200 μ M Smac-Ant peptide (AVPIAQK), cisplatin (50 μ g ml −1 ), or a combination of the two agents for 24, 48, and 72 h ( B ). One-way ANOVA with post-test for linear trend was used to analyse the data.
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    Relative viability (MTS assay) of Caki1 cells treated with indicated concentrations of Smac-Ant peptide (AVPIAQK) alone or in combination with cisplatin (50 μ g ml −1 ) for 24 h ( A ). The cells were exposed to 200 μ M Smac-Ant peptide (AVPIAQK), cisplatin (50 μ g ml −1 ), or a combination of the two agents for 24, 48, and 72 h ( B ). One-way ANOVA with post-test for linear trend was used to analyse the data.

    Journal: British Journal of Cancer

    Article Title: Double inhibition of XIAP and Bcl-2 axis is beneficial for retrieving sensitivity of renal cell cancer to apoptosis

    doi: 10.1038/sj.bjc.6604268

    Figure Lengend Snippet: Relative viability (MTS assay) of Caki1 cells treated with indicated concentrations of Smac-Ant peptide (AVPIAQK) alone or in combination with cisplatin (50 μ g ml −1 ) for 24 h ( A ). The cells were exposed to 200 μ M Smac-Ant peptide (AVPIAQK), cisplatin (50 μ g ml −1 ), or a combination of the two agents for 24, 48, and 72 h ( B ). One-way ANOVA with post-test for linear trend was used to analyse the data.

    Article Snippet: The cell-permeable peptide Smac-N7 (AVPIAQK-PRQIKIWFQNRRMKWKK) bound to an antenopedia sequence facilitating incorporation into the cells was from Calbiochem.

    Techniques: MTS Assay

    Phase contrast (left), Hoechst 33342 (middle), and Giemsa (right) photographs of Caki1 cells treated with 200 μ M Smac-Ant peptide, 50 μ g ml −1 cisplatin, or a combination of the two agents for 24 h ( A ). ( B ) Higher magnification of phase contrast (upper panel) and Hoechst 33342 (lower panel) photographs of the same field of Caki1 cells treated with a combination of Smac-Ant peptide (AVPIAQK) (200 μ M ) and cisplatin (50 μ g ml −1 ). Cells undergo typical apoptotic morphological changes (condensed fragmented nuclei with formation of apoptotic bodies) as indicated by arrows.

    Journal: British Journal of Cancer

    Article Title: Double inhibition of XIAP and Bcl-2 axis is beneficial for retrieving sensitivity of renal cell cancer to apoptosis

    doi: 10.1038/sj.bjc.6604268

    Figure Lengend Snippet: Phase contrast (left), Hoechst 33342 (middle), and Giemsa (right) photographs of Caki1 cells treated with 200 μ M Smac-Ant peptide, 50 μ g ml −1 cisplatin, or a combination of the two agents for 24 h ( A ). ( B ) Higher magnification of phase contrast (upper panel) and Hoechst 33342 (lower panel) photographs of the same field of Caki1 cells treated with a combination of Smac-Ant peptide (AVPIAQK) (200 μ M ) and cisplatin (50 μ g ml −1 ). Cells undergo typical apoptotic morphological changes (condensed fragmented nuclei with formation of apoptotic bodies) as indicated by arrows.

    Article Snippet: The cell-permeable peptide Smac-N7 (AVPIAQK-PRQIKIWFQNRRMKWKK) bound to an antenopedia sequence facilitating incorporation into the cells was from Calbiochem.

    Techniques: